It is very crucial to diagnose cancer biomarkers at the early stages. The early detection of the disease can enhance the preventive measures, increase curability of the disease, reduce health care costs, and finally, improve the quality of life for patients. This paper explains innovation in the field of complex diseases diagnosis, by detecting the disease antigen using the interdigitated gold electrode circuit incorporated with gold nanoparticles under a controlled self-driven flow condition in a microfluidic based biosensor.

We implement to design the biosensor which can escalate the detection to couple of folds. The research mainly is focused on developing a surface modification protocol for better sensitivity under the shear flow rate conditions using carboxylic functionalized gold nanoparticles. In this article, the role and functionality of the carboxylic gold nanoparticles were explained for signal enhancement in the field of biosensing. The experimental results provide the evidence of disease-specific antigen (CA-125) detection and the enhancement over previously researched on CNTs and non-nanoparticles based sensing platform from a micro volume of biofluid sample using the carboxylic gold nanoparticles modified interdigitated electrodes under capillary flow condition. 

Keywords:

Biosensor, Interdigitated gold electrodes, Microfluidic channel, Gold nanoparticles, Capacitance measurements

Debdyuti Mandal, Bharath Babu Nunna, Shiqiang Zhuang1, Durgamadhab Misra2, Md Nasir Uddin Bhuyian2, Joo Un Lee3, Eon Soo Lee1*

ENCHANCEMENT IN SENSITIVITY WITH GOLD NANOPARTICLES-BASED BIOSENSOR UNDER SHEAR FLOW CONDITION. Nano-Structures & Nano-Objects