The detection and determination of the cancer biomarkers is very crucial to diagnose at the early stages. We implement to design the biosensor which can improve the detection by reducing the process time, cost and space. The research approach mainly is focused on developing a surface modification protocol for better sensitivity under the shear flow rate conditions using carbon nanotubes (CNTs).

The interdigitated electrode transducer was modified using functionalized CNTs for signal enhancement. The biosensor was integrated with PDMS microfluidic channels for controlled self-driven flow. In this article, the role and functionality of the CNTs for signal enhancement are summarized. The experimental results provide the evidence of disease-specific antigen (CA-125) detection from a micro volume of biofluid sample using the CNTs modified interdigitated electrodes under capillary flow condition. 

Citations: Debdyuti Mandal, Bharath Babu Nunna, Shiqiang Zhuang, Subhajit Rakshit, and Eon Soo Lee. "Carbon nanotubes based biosensor for detection of cancer antigens (CA-125) under shear flow condition." Nano-Structures & Nano-Objects(2017).

Full Article: https://doi.org/10.1016/j.nanoso.2017.09.013