Nano Biochip for disease detection, diagnosis and monitoring


  - Biochip projects for detections of multiple biomarkers in a single chip

  - Self-separation of plasma from whole blood flow in a unique straight microchannel (no pump and no centrifugal or gravitational forces)

  - microscale flow dynamics with fluid and particles interactions. (gel particles) 

  - Nanofluidics on nanoimprinting applications

 

We are also applying the micro and Nano technology and new materials to the research for biochip micro devices for non-invasive disease detection and diagnosis usingboth innovative sensing technology and unique microchip design developed in the lab, with the collaborations with researchers at nearby medical research centers and Brookhaven National Laboratory. Cancer is one of the major causes of non-accidental death in human. Early detection and diagnosis of the disease allows clinician to take suitable treatment and to improve the patient’s survival rate. The micro biochip helps to diagnose the cancer at earlier stages with its innovative and state of the art ‘sensing technology’- to identify the existence of cancer antibodies in the micro volume of blood sample. When the blood flows through the micro channels of the biochip, the cancer antigens interact with the pre-coated cancer antibodies in the micro channel. The biochip detects the existence of antigens by sensing the antigen-antibody interaction. The sensing technology provides both qualitative and quantitative results of cancer antigens in blood sample. Thus we can diagnose both the existence and the severity of cancer using the micro biochip. The institutes collaborated in this research are Princeton University-The Princeton Institute for the Science and Technology of Materials (PRISM),  NNIN- National Nano technology Infrastructure Network (Penn state university), BNL-Brookhaven National laboratory, CUNY Advanced Science Research Center, Hackensack Medical Centers and Weill Cornell Medical School and NJIT MFC-Micro fabrication Center.

(Abonics, Inc. spun off from this research in May 2018 has been pursuing the external funding from federal agencies, private foundation and angel investors.)

 

 

Non-PGM Graphene Catalysts for Electrochemical Energy Systems

- Graphene catalyst & Graphene-MOF catalyst research 

- Stability of the new set of catalysts 

- Half-cell/Single cell characterization of performance stability research 

- Fuel cell stack and system characterization study 

 Advanced Energy Systems and Microdevices Laboratory’s energy researches are focused on the non-platinum group metal (Non-PGM) catalysts and their applications for electrochemical energy systems and industrial applications. Non-PGM catalysts have a huge potential due to the very low raw material cost compared to that of PGM catalyst in many applications spanning from catalytic devices in filtering systems or petroleum processing systems to electrochemical systems such as fuel cells or metal-air batteries, but there is still huge gap between the PGM and non-PGM to be filled by researches. The major research activities of the lab include 1) synthesizing new non-PGM catalysts for new energy systems from the sources of carbon materials (eg. Graphene) with addition of nitrogen, transition metals, and porous materials to modify the characteristics and enhance the catalytic performance of the synthesized catalysts, 2) characterizing the physical, chemical and electrochemical properties of the new synthesized catalysts by XPS, Raman, SEM, TEM, XRD, RRDE and electrochemical testing station, and 3) investigating the reaction mechanism of the new synthesized catalysts through experimental methods for a fundamental understanding of the reaction mechanism. We are getting research supports from or collaborating with Brookhaven National Laboratory- Center for Functional Nanomaterials (CFN), Priinceton University - The Princeton Institute for the Science and Technology of Materials (PRISM), Rutgers XPS facility center, Montclair State University - Material Characterization Laboratory and NJIT Otto York Center for Material characterizations for a top-notch technology supports for characterizations. The research will provide a substantial pathway to the new cost-effective and fuel-efficient energy conversion system for the next generation energy society.

 

 

Flow and Thermal Management for Energy Systems

- Microfluidics in micro- and nano-scale flow

- Porous-Wall MicroChannel Flow and Thermal Analysis

- Fluid and thermal systems analysis: battery and fuel cell

- Electrochemical energy conversion technology: battery and fuel cell 

- Thermal characterization study 

- Microscale thermo-fluid and imaging

- Optical imaging and flow dynamics analysis

- Experimental and Numerical investigations on flow and heat transfer in energy and electronic devices

The needs for flow characterization and thermal management are increasing with the reduced sizes but increased energy density and increased power consumption rate not only in small electronics as predicted by Moore’s law but also in megawatt power plant systems. To successfully control the high energy-density systems, not only air cooling but also liquid cooling is adapted, and those cooling methods require precise physical understanding of flow dynamics and thermal phenomena with innovative flow and thermal design factors. The main objectives of the researches are (1) to understand the flow behaviors including the flow regime on the diverse flow conditions and liquid water drop dynamics and frictional characteristics, and (2) to analyze heat transfer characteristics of the gas phase and gas-liquid two-phase flow in the porous and solid microchannels, and (3) to characterize the cooling enhancement and the performance factors in microchannel and microporous channel flow with and without electro-osmotic effects.