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Metal-organic framework-modified nitrogen-doped graphene oxygen reduction reaction catalyst synthesized by nanoscale high-energy wet ball-milling structural and electrochemical characterization


It is very crucial to diagnose cancer biomarkers at the early stages. The early detection of the disease can enhance the preventive measures, increase curability of the disease, reduce health care costs, and finally, improve the quality of life for patients. This paper explains innovation in the field of complex diseases diagnosis, by detecting the disease antigen using the interdigitated gold electrode circuit incorporated with gold nanoparticles under a controlled self-driven flow condition in a microfluidic based biosensor.

The integrated module of microfluidics with the biosensor is of great research interest with the increasing trend of lab-on-the chip and point-of-care devices. Though there are numerous studies performed on associating the microfluidics to the biosensing mechanisms, the study of the sensitivity variation due to microfluidic flow is very much limited. In this paper, a study of the sensitivity variation while detecting the CA-125 antigen using interdigitated electrodes, ‘with’ and ‘without’ microfluidic flow of CA-125 antigens was performed.